The unprecedented crisis that COVID-19 has suddenly unleashed upon the world is affecting all aspects of society and is likely to have an effect on the routes and characteristics of both regular and irregular migration. Smuggling of migrants and trafficking in persons will also be affected in certain ways by the crisis. Many factors shape the dynamics of these two criminal phenomena, from the international political and security landscape to macro socio-economic dynamics and national law enforcement capacity - all of which have been affected by the global pandemic. The impacts of the COVID-19 crisis, and of the measures adopted by governments to contain it, differ across the globe, and the effects of these measures on smuggling of migrants and trafficking in persons are likely to vary from country to country and from region to region. This Research Brief analyses possible scenarios of how smuggling of migrants and cross-border trafficking in persons are likely to be affected by the COVID-19 crisis along mixed migration routes to two important destination regions: North America and Europe.