Context (key issues addressed and population served) Rome is one of the largest hub for migration and hosts a consistent homeless population, while Southern Italy Regions have been the first destination for many migrants crossing the Mediterranean, therefore the intervention was implemented for the areas which are under the biggest pressure in terms of quantitative presence. Rome has a Social Assistance Service with a call centre and an outreach equipe, working 24/7 to ensure a quick and highly mobile response to the need of the target population. Rome also hosts 1300 homeless in its centres and delivers 40.000 food support (lunch, dinner) per day. INTERSOS, previously to the pandemic, had already implemented a service called INTERSOS24, a medical centre located in the VIIth District of Rome which offers medical and health assistance to a wide range of targets, going from impoverished Italians, to undocumented and documented migrants, to Roma and homeless. The structure is open 5/7 5 hours every day, now closed for COVID-19 emergency and operational in the City with 2 mobile units, and is assisted by a multidisciplinary equipe which includes a medical referent (MD), 2 medical doctors, a nurse, a clinical psychologist and psychotherapist, 2 cultural mediators. In the centre is also possible to access specialistic medical assistance for SGBV victims, mental health vulnerabilities, work and GBV and exploitation, to receive orientation to general and specialistic public medical services, communities health promotion, orientation to INTERSOS internal services (job orientation and workshops, soft-skills) orientation to social services, both institutional and grassroots (social, legal, job assistance). March 2020 was the begin of the first pandemic wave, and to design and implement a quick, standardized and accountable response was the paramount goal of this whole intervention. The baseline for Rome presented a number of 76000 (2014 ISTAT est.) undocumented migrants, and between 3500 and 5000 estimated homeless . The city hosts 15.2% of the homeless population in Italy (ISTAT, 2014). These composite population represents a particularly hard to reach target, being for the majority living either in informal dwellings or squatted buildings, while others make use of the refuge offered by City shelters. The agreement with the city of Rome begun the (19th March, MoU1 ) through a Partnership Agreement, followed by a second agreement (20th May, MoU2 ), a third (16th November, MoU3 ). A fourth (20th December, MoU4 ) had been signed the City of Rome and Local Health Authority (ASL Roma 2, MoU4), and a fifth (13th January 2021) with Local Health Authority (ASL Roma 2, MoU5).